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Reliability guarantee framework for the Sichuan–Tibet Railway

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 480-491 doi: 10.1007/s42524-021-0170-4

Abstract: Consequently, countermeasures are necessary and urgent to ensure its safety and reliability in the wholeThis study proposes a novel reliability framework to guarantee the ideal operation state of the Sichuan–TibetReliability application in many fields are summarized, including military equipment, rail locomotive,On the basis of the concept of the Nine-Connotation and the understanding of reliability transmission, innovating and establishing the management principle of great safety and great reliability over the

Keywords： Sichuan–Tibet Railway operational efficiency reliability guarantee Nine-Connotation implementation

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Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering

Bing WANG, Qingbin CUI, Shuibo ZHANG

Frontiers of Engineering Management 2019, Volume 6, Issue 2, Pages 239-248 doi: 10.1007/s42524-019-0018-3

Abstract: When designing contracts, governments usually offer incentives while requiring cost or time guaranteeThis study fills this gap by developing a methodology that analyzes the appropriateness of guaranteeIn this study, a contract reliability index is constructed, and a process of evaluating contract reliability

Keywords： infrastructure development contract design contract reliability guarantee provision contract engineering

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Current status and prospects of reliability systems engineering in China

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 492-502 doi: 10.1007/s42524-021-0172-2

Abstract: This study provides a systematic overview of the advent and evolution of reliability systems engineering

Keywords： reliability effectiveness model-based systems engineering reliability systems engineering

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Human reliability in maintenance task

Pacaiova HANA,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 2, Pages 184-188 doi: 10.1007/s11465-010-0002-4

Abstract: The importance of considering the reliability of maintenance tasks and the method to reach it are also

Keywords： maintenance risk assessment failure reliability prevention

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

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An overview of the reliability metrics for power grids and telecommunication networks

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 531-544 doi: 10.1007/s42524-021-0167-z

Abstract: In this study, we conduct a comprehensive overview of the development of reliability metrics for powerThe main purpose of this review is to promote and support the formulation of communication network reliabilitymetrics with reference to the development of power grid reliability.We classify the metrics of power grid into the reliability of power distribution and generation/transmissionThen, we exhibit and discuss the difference between the situations of the reliability metrics of the

Keywords： reliability metrics power grids telecommunication networks

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System reliability and system resilience

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 615-619 doi: 10.1007/s42524-021-0176-y

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Special issue: Reliability management of complex system

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 477-479 doi: 10.1007/s42524-021-0175-z

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Reliability design method for steam turbine blades

SHI Jinyuan

Frontiers in Energy 2008, Volume 2, Issue 4, Pages 363-368 doi: 10.1007/s11708-008-0073-7

Abstract: The purport and calculation method for blade reliability are expounded.The fatigue strength and the vibration design reliability of turbine blades are determined with the aidSome blade reliability design calculation formulas for a dynamic stress design method, a safety ratiodesign method for fatigue strength, and a vibration reliability design method for the first and secondThis research may provide some scientific basis for reliability design of steam turbine blades.

Keywords： design reliability force probability purport reliability design

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Service Security of Underwater Tunnel Lining Structures and Corresponding Guarantee Countermeasures

He Chuan,Liu Sijin,Zhang Yuchun and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 44-51 doi: 10.15302/J-SSCAE-2017.06.007

Abstract:

This paper analyzes four aspects of the safety problems in tunnel lining structures: design and construction, environmental erosion, sudden natural disasters, and sudden accidents. A survey of underwater tunneling such as the Huangpu River’s cross-river tunnel and the underground traffic tunnel in Shanghai was carried out, and the status quo of China’s underwater tunnel lining structure was analyzed. Based on these analyses, countermeasures guaranteeing the long-life security of underwater tunnel structures are being sought regarding tunnel construction, structural performance degradation, sudden natural disasters, and sudden accidents. These countermeasures are being sought to effectively protect and ensure the service performance of the tunnel structures during their entire life cycle. These security measures can ensure the safe performance of the structure during its entire life cycle, even under long service times. This research can serve as a reference for enhancing the structural security of underwater tunnels and other major tunnel structures.

Keywords： underwater tunnels service security security guarantee countermeasures long life structural defects

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A reliability growth model for 300?MW pumped-storage power units

Jinyuan SHI , Yu YANG , Zhicheng DENG ,

Frontiers in Energy 2009, Volume 3, Issue 3, Pages 337-340 doi: 10.1007/s11708-009-0032-y

Abstract: A reliability growth model for pumped-storage power units is presented.fitting on checking the model’s parameters are given together with analysis results concerning the reliabilityOn site operation, reliability data show that the reliability growth model conforms to rules of reliabilityAnalysis results of reliability growth indicate that measures taken for improving maintenance and operationby the pumped-storage power companies are effective and that the reliability of the 300MW pumped-storage

Keywords： pump-storage power unit availability reliability growth reliability prediction

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An exploratory study for predicting component reliability with new load conditions

Zhengwei HU, Xiaoping DU

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 1, Pages 76-84 doi: 10.1007/s11465-018-0522-x

Abstract: Reliability is important to design innovation.For many existing components used in the new product, their reliability will change because the appliedThen the new reliability must be re-evaluated.with new Loads given the following information: The original reliability of the component with respectSince the information is limited, the re-evaluated component reliability is given by its maximum and

Keywords： reliability component failure mode prediction random variable

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Principle of maximum entropy for reliability analysis in the design of machine components

Yimin ZHANG

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 1, Pages 21-32 doi: 10.1007/s11465-018-0512-z

Abstract: We studied the reliability of machine components with parameters that follow an arbitrary statisticalWe obtained the first four moments of the state function for reliability analysis and design.This function was used to calculate the reliability of the machine components, including a connectingThis study provides a design methodology for the reliability of mechanical components for practical engineering

Keywords： machine components reliability arbitrary distribution parameter principle of maximum entropy

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Safety Guarantee Measures for Subsea Shield Tunnel Segments Based on Life Cycle Deterioration Analysis

Liu Sijin,He Chuan,Sun Qi and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 52-60 doi: 10.15302/J-SSCAE-2017.06.008

Abstract:

The segment joint is the weak link in the lining structure of subsea tunnels, as it is under the continuous coupled effect of high water pressure and the corrosive seawater environment. If its performance deteriorates, it will seriously affect the safety of the lining structure of entire subsea shield tunnels. Based on an analysis of existing research into segment joint erosion and deterioration, a tunnel service time factor is introduced. Considering the influence of seawater pressure infiltration and chloride ion erosion and migration, a model analyzing the erosion and deterioration of the segment joint over its whole life cycle was subsequently established. The law governing the progressive erosion and deterioration of the segment joints of subsea tunnels over the entire life cycle was analyzed. The effects of seawater pressure and ion concentration on the erosion, deterioration, and steel corrosion of segment joints were studied. Based on the analysis of erosion and deterioration over the entire life cycle, economic and rational measures to ensure the long-term safety of the segment lining structure of subsea shield tunnels were proposed.

Keywords： shield tunnel safety guarantee deterioration analysis ion erosion segment joint